Report of the DEPO PROVERA STUDY
Freedom of information.
What is DEPO-PROVERA?
Depo Provera (medroxyprogestterone) is a long acting substance with properties simular to natural progesterone, a hormone normally secreted by the human body. It's primary use is to provide long term suppression of ovulation in females. As such a contraceptive it is injected at three-month intervals in doses generally of 150 mg.
The drug is manufactured by the Upjohn Company and marketed in 80 countries around the world. It has the approval of the World Health Organization (WHO), the U.S. Agency for International Development, (USAID) and the International Planned Parenthood Federation for use as a contraceptive agent. Estimates of use by woman run to 5,000,000 over the past two decades Depo Provera is for a patient who refuses or is unable to accept responsibility of other contraceptive methods, or is incapable or unwilling to tolerate the side effects of conventional oral contraceptives or is one for whom other methods of contraception are contraindicated or have repeatedly failed. "
Read this in shorthand: the POOR, who often lack sufficient contraceptive education or access to contraceptives, and the MENTALLY RETARDED. To submit the relatively helpless to Depo Provera without a substantiated clear demonstration of CANCER SAFETY, would in our view be an outrage. The concept of informed consent --always of dubious value in any doctor -patient relationship--is utterly meaningless in this population . We are further concerned that there is little way to control the use of the drug in middle class women once approved for contraception, the patient leaflet notwithstanding.
EXCESSIVE CARCINOMA-IN-SITU IN HUMANS
A June 17, 1974 analysis of the Upjohn Depo Provera Safety data by an FDA statistician, Bertram Litt, concluded that cervical cancer in situ occured far in excess of expected rates calculated by the third National Cancer Survey. Conducted by the National Cancer Institute (NCS). White Depo Provera users on a dosage of 150mg/3 mos. of Depo Provera with supplemental Estrogen had 9.1 times more carcinoma-in -situ than expected; blacks 4.8 times more. White Depo Provera users at 300-400 mg/6 months had 7.3 times the expected incidence. All white Depo Provera users had 4.9 times carcinoma -in -situ: non whites, 3.1 times.
Litt also noted these calculations were based on just 22 of known cases of carcinoma -in- situ occuring in the Depo Provera trials and that there were, in fact, a total of 35 cases known. The women in the Upjohn studies have not been followed since then. Moreover, there were Depo Provera studies which were not submitted at all in the Upjohn NDA. The median time of occurance was 18 months, after exposure to Depo Provera. FDA nevertheless dismissed the human figures on three grounds. There was insufficient lag time between exposure and onset of carcinoma-in -situ for the cases to have been drug induced.
This drug has ruined too many families; in the month of December 2001 Depo Provera took the life of a 26 year old woman. In January 2001 Depo Provera took the life of my granddaughter.
I have pages and pages on DEPO PROVERA. If any one was to look at the number of women across America who have suffered, it's no wonder the Upjohn Company does't want to BAN it; it's all about the all mighty DOLLAR. The HELL with the families that are suffering, I have read pages and still doing research on this POISON that is going in young teenagers I am praying Depo Provera will be taken off the shelves. This drug has ruined my daughter's life. She has suffered enough for twenty years. This drug must be stopped from being injected in people.
I'll never understand WHY Depo Provera was ever FDA approved. I have one wish to meet the JERKS who signed the OK slip so they can look my granddaughter in the eye and explain why her mother isn't getting well and may not ever get well and she might get cancer but yet Depo Provera was approved.
When Constnace read what I just wrote her eyes were watering. She feels BETRAYED by our Goverment. Constance was not given the COLD HARD FACTS OF THIS DRUG. IT KILLS.
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